in windows 10, i can personal say that HFS and Chrome are not virus, i have not had windows defender come up ans say x and x is infected, i would assume an extension in chrome would be the cause, and i would have you double check you system, as the windows defends picks up a registry issue as the virus.. (as seen via the picture in your post)
Windows defends has never "tagged" HFS as a problem, and i've made sure HFS (talking with Microsoft and with reports) wouldn't be flagged as long as "if" it didn't violate x and x rules...(this was done for windows 7 and 8 widnows 10 is still new...) there are other post with HFS was being considers a virus....(false positive)
If you can confirm that it is a false positive, then post the result to Microsoft (only if you double check it! (and confirm that it is a false positive: report it to Microsoft:
https://www.microsoft.com/security/portal/mmpc/developer/resources.aspxfurther look into what is being detect also via you picture:
http://www.microsoft.com/security/portal/threat/Encyclopedia/Entry.aspx?Name=Trojan:Win32/Skeeyah.C!plockdefinition of why it flagged that file (which is a setting as it is located in the "Program datafolder"....) meaning that if it was HFS, the it would show your HFS path...
Trojan:Win32/Skeeyah.C!plock
"Trojans are a type of malware that try to look innocent to convince you to install them on your PC.
They can steal your personal information, download more malware, or give a malicious hacker access to your PC."
since it "stop" with a working new fresh download, there is probably something wrong with your HFS excutable, there fore a trojan or virus that "hijacks HFS" (excutables specficaly), could be at fault here....
http://www.rarst.net/software/image-file-execution-options/which leads me to believe that you machine may still have that virus...
windows defends done't protect you from everything...
i would recommend you download and install malwarebytes and run a scan on the items and a full system scan...
https://www.malwarebytes.org/downloads/and also scan your hfs executable by testing it here, there are 2-3 that warn as hfs (as false positive)
https://www.virustotal.com/you can even use this site to scan the download links to HFS....
so yeah, good luck
