yes, but you need HFS 2.3
use event [upload completed]
http://www.rejetto.com/wiki/index.php?title=HFS:_Event_scriptsHFS 2.3 has its own scripting language, but you don't need to learn it, you can just call an external program of your own using the {.exec.} command, and passing at command-line all the information you need, like %item-resource%.
Well, you may need some HFS scripting if you want the output to be used to make something inside HFS, like {.add to log|conversion succeeded.}